EPConDB News RSS Feed RSS feed for EPConDB news en-us Friday, February 15, 2007 01:00:00 Friday, February 15, 2007 01:00:00 http://blogs.law.harvard.edu/tech/rss epcondb@pcbi.upenn.edu epcondb@pcbi.upenn.edu Easily find EPConDB Studies 02 Apr 2008 01:00:00 EDT http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news11 news11
  • Find all EPConDB studies that have a Gene List here.
  • To find a list of studies where your gene of interest is differentially expressed, use the "Differential Expression of a Specific Gene" Query.
  • A simple text search of all study annotation is provided here.
  • Narrow your search for studies further by using the "Query for Studies" section of our Query Page. ]]> An Expression Study of FoxA2 in Mature beta Cells is Now Available 15 Feb 2008 01:00:00 EDT http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news10 news10 Study "Foxa2 controls vesicle docking and insulin secretion in mature beta-cells" has been released. This study includes an executive summary and a list of differentially expressed genes (PaGE analysis).

    Findings from this study:

    • Foxa2 inactivation in mature beta cells induces hyperinsulinemic hypoglycemia in Foxa2loxP/loxP,Pdx1-CreERT2 adult mice through alterations in intracellular second-messenger signaling that redistribute the insulin granules into the readily releasable pool.
    • Foxa2 is required for both fetal pancreas development and the function of mature beta cells.

    Gao et al. Foxa2 Controls Vesicle Docking and Insulin Secretion in Mature beta Cells. Cell Metabolism. 2007. 6:267-279

    ]]>         EPConDB News Now Seen at BetaCell.org 17 Dec 2007 01:00:00 EDT http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news9 news9 BCBC website will be carrying the EPConDB RSS feed. This will enable users of the BCBC website to easily get updates on new features and data in EPConDB.]]> Release of EPConDB 4.1 1 Nov 2007 01:00:00 EDT http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news8 news8 Version (4.1) of the EPConDB website is now available.

    The new features of this release include:

    1. New studies
    2. Comparison profiles
    3. Better display of BCBC regents
    4. Clickable network diagram of transcription factors involved in pancreas and islet cell development

    The new studies are:

    • 2440 - T Cell Mediated B-cell Damage and Repair in NOD Mice
    • 2421 - Innocuous vs. Destructive Insulinitis
    • 3021 - Neurogenin3 deficiency and Embryonic Pancreatic Gene Expression
    • 2060 - Human Tissue Survey From Massively Parallel Signature Sequencing (MPSS)
    • 18 non-pancreatic DGAP Studies

    The study summaries are displayed at betacell.org as well as EPConDB.

    ]]>         Preview Release of EPConDB 4.1 21 Sep 2007 01:00:00 EDT http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news7 news7 The next version (4.1) of the EPConDB website is now available for preview.

    The new features of this release include:

    1. New studies
    2. Manually curated study summaries
    3. Comparison profiles
    4. Better display of BCBC regents
    5. Clickable network diagram of transcription factors involved in pancreas and islet cell development

    The new studies are:

    • 2440 - T Cell Mediated B-cell Damage and Repair in NOD Mice
    • 2421 - Innocuous vs. Destructive Insulinitis
    • 3021 - Neurogenin3 deficiency and Embryonic Pancreatic Gene Expression
    • 2060 - Human Tissue Survey From Massively Parallel Signature Sequencing (MPSS)
    • 18 non-pancreatic DGAP Studies

    The study summaries are displayed at betacell.org as well as EPConDB.

    ]]>         Release 4.0 of the EPConDB web site. 5 May 2007 01:00:00 EDT http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news6 news6 Differentially Expressed Genes ]]> A new web site design for EPConDB. http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news5 news5 5 May 2006 01:00:00 EDT EPConDB Version 3.44 released http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news4 news4 28 Mar 2007 01:00:00 EDT Version 3.44 of the EPConDB website has been released. EPConDB is a resource of the Beta Cell Biology Consortium and contains information on genes expressed in cells of the pancreas and their transcriptional regulation. EPConDB Version 3.44 includes: The following studies have been added to the Experiments page. GSIS study of rat INS1 cell lines Lipotoxicity study of rat INS1 cell lines FoxA1 and beta cell function HNF4alpha in beta cell function Inducible Ngn3 embryonic stem cells Sox4 null mice e12.5 pancreas Beta cell growth in Tcf-1 deficient mice Survivin transgenic mice pancreatic islet profile Genome-wide location analysis of HNF transcription factors in hepatocytes and pancreatic islets New lists of differentially expressed genes from the following studies have been added to the Experiments page (use the Analysis Result link) and the queries for Up and Down regulated gene expression. Type 2 diabetic individuals versus normal individuals Cyclophosphamide-induced beta cell destruction in NOD mice FoxA1 knockout versus wild type mice HNF4alpha knockout versus wild type mice Two lists of genes with HNF1alpha or HNF6 promoter binding sites, identified by ChIP-Chip assays are provided: Genome-wide location analysis of HNF1 alpha in islets Genome-wide location analysis of HNF6 in islets Gene expression profiles from six new studies were added to the profiles for individual genes. Please see the EPConDB website for more details. Genome-wide location analysis of HNF1 alpha in islets Genome-wide location analysis of HNF6 in islets Gene expression profiles from six new studies were added to the profiles for individual genes. Please see the EPConDB website for more details.. . EPConDB version 3.43 released http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news3 news3 EPConDB web site has been released.

    The new EPConDB site release includes:

    • Five new lists of differentially expressed genes added to the Experiments page and the queries for Up and Down regulated gene expression.
    • The display of the differentially expressed gene lists has been updated. Users are able to sort the gene lists based upon confidence or fold change, and the genes are colored coded (up-regulated in red, down-regulated in green).
    • Ten new pancreatic transcription factors (e.g., Pax4) have been added to the Predicted Transcription Factor Target Gene Query.
    • The display of the gene result page from queries has been changed to include Entrez gene annotation and links to the gene page, expression profiles and the genome browser.
    • Two new expression studies have been added to the expression profiles for individual genes.

    ]]>     20 Sep 2006 01:00:00 EDT     Analysis results from microarray studies have been provided as gene lists. http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news2 news2 20 Feb 2006 01:00:00 EDT EPConDB RNA pages include links to BCBC protein antibodies. http://www.cbil.upenn.edu/epcondb41/displayRSS.jsp?item=news1 news1 BCBC web site. ]]> 5 May 2006 01:00:00 EDT