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Cardiovascular Biology related papers from the Davies lab

Davies, P.F., Shi, C., DePaola, N., Helmke, B.P., Polacek, D.C. 2001. Hemodynamics and the focal origin of atherosclerosis : A spatial structural, gene expression, and functional approach. Annals NY Acad. Sciences 947: 7-18.

Davies P.F., Helmke, B.P. 2002. The cytoskeleton under external fluid mechanical forces. Annals Biomedical Engineering 30: 1-13.

Davies, P.F., Polacek, D.C., Shi, C., Helmke, B.P. 2002. The Convergence of Hemodynamics, Genomics, and Endothelial Structure, in Studies of the Focal Origin of Atherosclerosis. Biorheology 39: 299-306. PMID: 12122245

Romanenko, V., Davies, P.F., Levitan, I. 2002 Dual effect of fluid shear stress on volume regulated anion current in bovine aortic endothelial cells. Am. J. Physiol. 282: C708-718. PMID: 11880259

Zhang J. C.L., Helmke B.P., Shum A., Yu W. W.,. Lu M. M, Davies P. F., Parmacek M.S.. 2002. SM22: A Novel Cytoskeletal Protein Expressed in a Cell Lineage-Restricted Pattern. Mechanisms of Development 115:161-166.

Davies, P.F. 2002. Multiple Signaling Pathways in Flow Mediated Endothelial Mechanotransduction: PYK-ing the right location Arter. Thromb. Vasc. Biol. 22:1755-1757.

Davies, P.F., Zilberberg, J., Helmke, B.P. 2003. Spatial Microstimuli in Endothelial Mechanosignaling Circ. Research 92:359-370.

Rizzo V., Morton C., DePaola, N., Schnitzer, J., and Davies, P.F. 2003. Recruitment of endothelial caveolae into mechanotransduction pathways by flow-conditioning in vitro. Am. J. Physiol. 285:H1720-9.

Helmke, B.P., Davies, P.F. 2004. Imaging Live Cells under Mechanical Stress. In: Live Cell Imaging: A Laboratory Manual. Edited: Spector, D.L. and Goldman, R.L. Publ. Cold Spring Harbor Laboratory Press. pp 569-584.

Davies, P.F., Passerini, A.G., Simmons, C.A. 2004. Aortic valve: Turning over a new leaf(let) in endothelial phenotypic heterogeneity. Arterioscl. Thromb. Vasc. Biol. 24:1331-1333.

Kaufman, D.A., Albelda, S.M., Davies, P.F. 2004. Role of lateral cell-cell border location and extracellular/transmembrane domains in PECAM/CD31 mechanosensation. Biochem. Biophys. Res. Comm. 320:1076-1081.

Simmons, C.A., Zilberberg, J., Davies, P.F. 2004. A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations. Annals Biomed. Eng. 32:1453-1459.

Davies, P.F. 2004. Molecular phenotypes of atherosclerosis: Fingering the perpetrators. Arterioscler. Thromb. Vasc. Biol. 24:1746-1747. PMID: 15472136

Davies, P.F., Spaan, J.A., Krams, R. 2005. Shear Stress Biology of the Endothelium. A position paper arising from the CalTech International Biofluid Mechanics Symposium. Annals Biomed. Eng. 33:1714-1718. PMID: 16389518

Fang, Y. Romanenko, V., Shi, C., Schram, G., Davies, P.F., Nattel, S., Levitan, I. 2005. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. Am. J. Physiol. 289:C1134-1144. PMID: 15958527

Magid, R., Davies, P.F. 2005. Endothelial protein kinase C isoform identity and differential activity of PKC in an athero-susceptible region of porcine aorta. Circ. Research 97:443-449. PMID: 16051884

DeLisser, H.M., Helmke, B.P., Cao, G., Pooler, P.M., Taichman, D., Fehrenbach, M., Zaman, A., Cui, Z., Mohan, G.S., Baldwin, H.S., Davies, P.F., Savani, R.C. 2006. Loss of PECAM-1 function impairs lung alveolization. J. Biol. Chem. 281:8724-8731

Fang Y., Mohler E., Hsieh E., Osman H., Hashemi S., Davies, P.F., Rothblat G.H., Wilensky R., Levitan I. 2006. Hypercholesterolemia suppresses Kir channels in aortic endothelium in vitro and in vivo. Circ. Research 98:1064-1071. Accompanying Editorial by W.F. Jackson.

Davies, P.F. 2007. Hemodynamics in the determination of the endothelial phenotype and flow mechanotransduction. In: ‘Endothelial Biomedicine; A Comprehensive Treatise’, Ed. Aird,.W.C. Cambridge University Press. pp 230-245.

Davies, P.F. 2007. Endothelial mechanisms of flow-mediated atheroprotection and susceptibility. Circ. Research 101:10-12.

Helmke, B.P., Davies, P.F. 2007. Chambers for examination of live cells under mechanical stress. Cold Spring Harbor Protocols doi:10.1101/pdb.ip32.

Trojanowski, J.Q., Hendricks, J.C. Jedrziewski, K., Johnson, B., Michel, K.E. Hess, R.S., Cancro, M.P., Sleeper, M.M., Pignolo, R., Teff, K.L., Aguirre, G.D., Lee, V.M.-Y., Lawler, D.F., Pack, A.I., Davies, P.F. 2008. Exploring Human/Animal Intersections: Converging Lines of Evidence in Comparative Models of Aging. J. Alzheimers and Dementia, 4:1-5. PMC2665932

Davies, P.F. 2008. Endothelial transcriptome profiles in vivo in complex arterial flow fields. Annals Biomed. Eng. 36:563-571.

Jimenez, J.M. and Davies, P.F. 2009. Hemodynamically-driven stent strut design. Annals Biomed. Eng. 37:1483-95. PMC2819751

Helmke, B.P., Davies, P.F. 2010. Imaging Live Cells under Mechanical Stress. In: Live Cell Imaging: A Laboratory Manual. 2nd Edition. Edited: Goldman, R.L., Swedlow, J., and Spector, D.L., Publ. Cold Spring Harbor Laboratory Press, pp 641-658.

Davies, P.F., Helmke, B.P. 2010. Endothelial Mechanotransduction. In: ‘Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissue’, Eds. Mofrad, R.K. and Kamm, R.D. Cambridge University Press. Chapt. 2. pp20-60.

Davies PF, Civelek M, Fang Y, Guerraty MA, Passerini AG. 2010. Endothelial Heterogeneity associated with Regional Athero-susceptibility and Adaptation to Disturbed Blood Flow in vivo. (Special Issue: Under-recognized Significance of Endothelial Heterogeneity). Semin Thromb Hemost 36:265-275.

Civelek, M., Manduchi, E., Stoeckert, C.J., Davies, P.F. 2011. Discovery approaches to the unfolded protein response (UPR) in athero-susceptible endothelium in vivo. Methods Enzymol. 489:109-127.

Waters SL, Alastruey J, Beard DA, Bovendeerd PH, Davies PF, Jayaraman G, Jensen OE, Lee J, Parker KH, Popel AS, Secomb TW, Siebes M, Sherwin SJ, Shipley RJ, Smith NP, van de Vosse FN. 2011. Theoretical Models for Coronary Vascular Biomechanics: Progress and Challenges. Prog. Biophys. Mol. Biol. 104:49-76.

Davies, P.F., Civelek, M. 2011. Endoplasmic reticulum stress, redox and a pro-inflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stress, Antioxid. Redox Signal. 15:1427-1432.

Guerraty, M.A., Grant, G., Pritchard, W.F., Karanian, J.W., Chiesa, O.A., Davies, P.F. 2011. Side-specific expression of activated leukocyte adhesion molecule (ALCAM/CD166) in patho-susceptible regions of swine aortic valve endothelium. J. Heart Valve Disease. 20:165-167.

Fang, Y., Davies, P.F. 2012. Site-specific MicroRNA-92a regulation of Kruppel-like Factors 4 and 2 (KLF4; KLF2) in athero-susceptible endothelium. Arterio. Thromb. Vasc. Biol. 32:979-987.

McIntire, L., Jimenez, J.M., Eskin SE, Davies, P.F. 2012. Chapt. 39: Rheology and Vessel Wall Stress. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 6th Edition. Editors: Marder VJ, Aird WC, Bennett JS, Schulman S, White GC, Colman RW. Publ. Lippincott Williams & Wilkins. pp516-535.

Han, J., Zern, B., Shuvaev, V., Davies, P.F., Muzykantov, V. 2012. Acute and chronic shear stress differentially regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1 (PECAM-1). ACS Nano 6:8824-8836.

Davies P.F., Civelek M, Fang Y., Fleming, I. 2013. Regulatory mechanisms of pro-atherogenic endothelial phenotypes in complex hemodynamic shear stress regions in vivo. Cardiovascular Research, In Press.

Karamanian, A., Jimenez, J.M., Davies, P.F. 2013. Loss of flow-sensitive endothelial Claudin-5 expression at atherosusceptibility sites in vivo and increased permeability in vitro. Submitted.

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