What is plasmoMAP?
plasmoMAP is a network of functional interactions between proteins
encoded by the genome of the human malarial parasite Plasmodium falciparum. The network is reconstructed
by integrating various computational and functional genomics data within a Bayesian framework, providing putative
functional assignments for a large number of uncharacterized proteins, based on their associations with known
What is plasmoMAP useful for?
The authors intend plasmoMAP to serve as a knowledge-base of predicted protein-protein interactions within
P. falciparum, and as a starting point for experiments aimed at gene characterization.
While the current network is restricted to P. falciparum, we hope to extend it to other Plasmodium species as well.
Details of included data and network reconstruction are described in Date & Stoeckert (Date and Stoeckert,
Genome Research 2006; see below).
Model refinements, addition of new tools and queries, and changes in input data will be accomodated and
released as new versions of plasmoMAP.
How can I access the data contained in plasmoMAP?
How do I cite plasmoMAP?
- If you downloaded supplemental information from the Genome Research website on
March 6 or March 7 of 2006, you may have downloaded an outdated version. Genome Research has subsequently
uploaded the correct version.
- Errata: Linkages above a likelihood score threshold of 14 have 5x more
true positives than false positives, and not 10x, as reported in the text. This was an error in observation,
and does not affect the results in any way. Text on page 5, 'Analyzing a subset of higher confidence links'
section, should therefore be- 'Linkages above this threshold include 5x more true positives than false
positives, by the test of Figure 1'.
Page contents last updated on : June 4, 2007